Infertility treatment and inception of IVF centers in India

Infertility comes as one of the most talked about aspects in the medical science today and if we talk about its impact, it has led to big complications in most of the lives around. If we talk about its definition, infertility is largely about the inability of a men or women to conceive even after having unprotected sex for more than one year. The reasons for the same can be miscellaneous and same can be listed form the natural ones to certain lifestyle issues alongside.

Infertility treatments

Most of the infertility treatments involve the usage of certain fertility medication, medical devices, fertility surgery, or a proper combination of all as per the guidance of an expert physician. Moreover, if the sperm in the men is of good quality along with the properly functioning mechanics of the woman's reproductive structures (patent fallopian tubes, no adhesions or scarring), the IVF specialist may start with the prescription of proper ovarian stimulating medication.

 The physician might also recommend a  conception cap cervical cap, which the couples can brought in use at home by putting the sperm inside the cap and then placing the conception device on the cervix, or intrauterine insemination (IUI), where  the doctor  then put through the sperm directly into the uterus at the time of ovulation, via a catheter. Within all these methods, fertilization generally occurs within the body and if either of those doesn’t help the couples to achieve a full term pregnancy, the physician might prescribe the patient to undergo in vitro fertilization (IVF) treatment process.

 IVF and all those related techniques (ICSI,ZIFT, and GIFT) are been termed as assisted reproductive technology (ART) techniques. ART techniques initially commence with the stimulation of the ovaries in order to increase the egg production. Once the stimulation process goes through, the physician extracts one or more eggs from the ovary with the help of surgery, and mixes them with the sperm within a laboratory setting, with the purpose of producing one or more embryos in the process.

Fertilization process concludes outside the body, and the fertilized and developed egg is then inserted into the woman's reproductive tract during a process called embryo transfer. There are other medical techniques like tuboplasty, assisted hatching, and Pre-implantation genetic diagnosis which can be brought into use as well.

Inception of IVF clinics

The best IVF centre indonippon successfully implement the IVF (TEST TUBE BABY) and other ART service (diagnosing and treatment whilst performing IVF, ICSI, PESA and TESA/ICSI/ET) in Kerala is functioning since 1996 at Kadavanthra, Ernakulam. This is where the first children form IVF techniques were born in Kerela in 1997 which were conceived in 1996 from this centre.

The centre has facilitated the birth of more than 602 live babies (from IVF /ICSI) till now and the number is ever growing in the current medical environment. Thus, there was always a need of a good IVF centre and Embryologists in Mumbai and other parts of the country and this is where Goral Gandhi has come up as one do the most.

Antibubble Trajectory During Embryo Transfers in Donor EGG IVF does not Predict Success

By Goral Gandhi (Learn IVF Clinic) - the Transient motion of embryo transfer-associated anti-bubble was observed. This prospective study was performed to determine if this anti-bubble movement can predict a successful outcome. Transabdominal ultrasound-guided embryo transfer was performed in 187 recipients receiving identical hormone replacement therapy.

All embryo transfers were performed by the first author, using the Sureview embryo transfer catheter, in 30 ml of culture media. The observation was made of the catheter placement in relation to the endometrial surface and uterine fundus during embryo transfer. Ultrasound-guided tracking of anti-bubble within the uterine cavity was done immediately after the piston was depressed at the time of embryo deposition. The anti-bubble movement was upwards (group A) in 104 embryo transfers and downwards (group B) in 83 transfers. No movement of embryo-associated air out of the uterine cavity, either into the cervix or the intramural portion of the fallopian tube, was observed. The clinical pregnancy rate was similar in both groups: 47.12% in group A versus 45.78% in group B. The total implantation rate/embryo transferred was 19.34% in group A compared with 20.07% in group B. The movement of the embryo transfer-associated anti-bubble is unlikely to be a factor in predicting success in donor egg IVF cycles.

For More information you can visit here: Embryo Transfers

In Vitro Fertilization/Intracytoplasmic Sperm Injection for Male Infertility.

By Goral Gandhi (Indo Nippon IVF) - Progress in the field of assisted reproduction, and particularly micromanipulation, now heralds a new era in the management of severe male factor infertility, not amenable to medical or surgical correction. By overcoming natural barriers to conception, in vitro fertilization and embryo transfer (IVF-ET), subzonal sperm insemination, partial zona dissection, and intracytoplasmatic injection of sperm (ICSI) now offer couples considered irreversibly infertile, the option of parenting a genetically related child. However, unlike IVF, which necessitates an optimal sperm number and function to successfully complete the sequence of events leading to fertilization, micromanipulation techniques, such as ICSI, involving the direct injection of a spermatozoon into the oocyte, obviate all these requirements and may be used to alleviate severe male factor infertility due to the lack of sperm in the ejaculate due to severely impaired spermatogenesis (non-obstructive azoospermia) or non-reconstructable reproductive tract obstruction (obstructive azoospermia).

ICSI may be performed with fresh or cryopreserved ejaculate sperm were available, microsurgically extracted epididymal or testicular sperm with satisfactory fertilization, clinical pregnancy, and ongoing pregnancy rates. However, despite a lack of consensus regarding the genetic implications of ICSI or the application and efficacy of preimplantation genetic diagnosis prior to assisted reproductive technology (ART), the widespread use of ICSI, increasing evidence of the involvement of genetic factors in male infertility and the potential risk of transmission of genetic disorders to the offspring, generate major concerns with regard to the safety of the technique, necessitating a thorough genetic evaluation of the couple, classification of infertility and adequate counseling of the implications and associated risks prior to embarking on the procedure. The objective of this review is to highlight the indications, advantages, limitations, outcomes, implications and safety of using IVF/ICSI for male factor infertility to enable a more judicious use of these techniques and maximize their potential benefits while minimizing foreseen complications.

For more information you can visit here: in vitro fertilization

Ant bubble Trajectory During Embryo Transfers in Donor EGG IVF does not Predict Success

By Goral Gandhi (Learn IVF Clinic) - the Transient motion of embryo transfer-associated anti bubble was observed. This prospective study was performed to determine if this anti-bubble movement can predict a successful outcome. Transabdominal ultrasound-guided embryo transfers were performed in 187 recipients receiving identical hormone replacement therapy. 

All embryo transfers were performed by the first author, using the Sureview embryo transfer catheter, in 30 ml of culture media. The observation was made of the catheter placement in relation to the endometrial surface and uterine fundus during embryo transfer. Ultrasound-guided tracking of anti-bubble within the uterine cavity was done immediately after the piston was depressed at the time of embryo deposition. 

The anti-bubble movement was upwards (group A) in 104 embryo transfers and downwards (group B) in 83 transfers. No movement of embryo-associated air out of the uterine cavity, either into the cervix or the intramural portion of the Fallopian tube, was observed. The clinical pregnancy rate was similar in both groups: 47.12% in group A versus 45.78% in group B. 

The total implantation rate/embryo transferred was 19.34% in group A compared with 20.07% in group B. The movement of the embryo transfer-associated anti-bubble is unlikely to be a factor in predicting success in donor egg IVF cycles.

 For More information, you can visit here: Embryo Transfers

Goral Gandhi, Scientific And Laboratory Director at Indo Nippon IVF in Mumbai

Goral Gandhi is a Clinical Embryologist with more than 20 years of expertise in the field of IVF and Assisted Reproductive procedures. She is in charge of the structure and foundation of many active assisted conception labs in India and one in Ghana. She is always dedicated to keeping up remarkable achievement rate at all these labs or research centers.

In her 22 year’s journey, she has taken care of thousands of IVF and ICSI cases and has helped more than 3500 couples total their families. Goral has a productive involvement in giving training in IVF and has been sorting out academic lectures and hands-on workshops on all parts of IVF including IUI, ICSI, Verification, Trouble Shooting, and Laboratory Management since the year 2000. She has trained more than 350 embryologists from 13 nations.

She has set up extremely fruitful Fertility Preservation modules at various labs and her current research projects are centered around the choice of the most reasonable and ailment free embryo along with the unique conceivable implantation potential using PGD and PGS methods.

She has also edited a reading material (textbook) on Verification. Moreover, she has co-authored more than 30 sections in different therapeutic course books and has a few publications in national and universal journals. If you want to know more about her work, visit Goral Gandhi Website: https://indonipponivf.com/mrs-goral-gandhi/

How to get better out of an Embryo transfer process in IVF ?

Embryo transfer day can come over as a crucial day for any of the persons going for an IVF treatment and this comes along with lots of stress and worries in the process for both the couples alongside. While this would be bringing a lot of hope for both the partners seeking a solution for their infertility issues, this also brings along a greater risk of making everything go in vain in a matter of few days. So when this goes along, there are certain things that both the partners must keep in mind whilst planning through for an Embryo transfer process.

1. Look out for the best doctor around

Whilst this is going to be the best and most important decisions of your life being a couple, you must go forward to look around the best doctor who can help you all the way during the process. As this would help and support your overall IVF treatment in a big manner, it would also lay down a better foundation for your dreams of attaining parenthood eventually.

2. Get along with all the diagnosis required in the process

As a person goes through an IVF treatment, there is a list of diagnostics and tests that she has to go through during the same process which might include tests like Hormone profiling, semen analysis for the male partner, Trans -vaginal scan and so on. All these tests would play a crucial role in the treatment process

3. Diet and lifestyle

If we talk about the dietary schedule to follow during the IVF treatment process, the person must intake diet rich in Folic acid as it’s been said that Folic acid reduces the chances of any sort of birth defects in the child. Moreover, the patient can also opt for Folic acid supplements in case she is not finding it feasible to go on a diet for the same. Along with Folic acid, the Multivitamins must also be considered within the same process and it’s been stated by several medical professionals that Folic acid, whilst been taken along Multivitamins, improves the chances of IVF pregnancies by a great extent.

Other than diet, the person needs to make some crucial changes to another lifestyle in order to keep the unwanted stress and anxiety at bay. This can come through implementing various relaxation techniques, medication or through yoga. Whilst has been done, this could prove as a crucial aspect of the overall embryo transfer afterward.

Embryo transfer process: How to go about it during an IVF treatment?

Embryo transfer process is a part of the IVF treatment process and it can said to be the final step in the same process as well. Being a person seeking the IVF treatment, you might have been through weeks of medications, observations along with the egg retrieval process and finally it’s the time when the Embryo is going to be transferred to the uterus of the women after getting developed in a lab for 3-5 days.

This process comes as the most anticipated moment of the whole IVF journey and after months of treatment and medications, it’s that time when you will get to know the overall result about your IVF treatment. Therefore, understanding the overall process of taking care whilst going through the same always holds the key.

The Embryo transfer process

Once the embryo is developed and cultured in a lab dish, it is then implanted in the uterus of the women who are seeking pregnancy through IVF. It is a relatively easier Embryo transfer process than the Egg retrieval process and the patient can be discharged within 2-3 hours once the process is through. Going via ultrasound, the physician will use a fine transfer catheter to place the embryos through the vagina and cervix into the uterus. Once the transfer process is through, you will then be asked to lie on your back for about 30 minutes before getting discharged.

What happens after the embryo transfer?

The embryo transfer process isn’t that tough but what happens afterward is a journey full of anxiety and stress. As there will be a gap of almost two weeks between the embryo transfer and the first pregnancy test, the period in between comes along with all the stress and impatience for the person. As a result, you will get to see some symptoms like mood swings, fatigue, slight bloating and sore breast and it would be a bit hard to guess whether these are symptoms for premenstrual or Pregnancy.

This is where the patient becomes more confused in regards to the result of the overall IVF treatment and all they can do is to wait for the first pregnancy test.

Precautions to take after the embryo transfer

Although it’s been suggested that the patient can result with her daily routines after the embryo transfer process, she is still advised of proper bed rest for some time along with the consumption of some healthy foods in the process. Moreover, the patient is strictly prohibited for the consumption of alcohol and tobacco and this must be followed religiously. Moreover, for further information on the embryo transfer process and best IVF treatment around.