Antibubble Trajectory During Embryo Transfers in Donor EGG IVF does not Predict Success

By Goral Gandhi (Learn IVF Clinic) - the Transient motion of embryo transfer-associated anti-bubble was observed. This prospective study was performed to determine if this anti-bubble movement can predict a successful outcome. Transabdominal ultrasound-guided embryo transfer was performed in 187 recipients receiving identical hormone replacement therapy.

All embryo transfers were performed by the first author, using the Sureview embryo transfer catheter, in 30 ml of culture media. The observation was made of the catheter placement in relation to the endometrial surface and uterine fundus during embryo transfer. Ultrasound-guided tracking of anti-bubble within the uterine cavity was done immediately after the piston was depressed at the time of embryo deposition. The anti-bubble movement was upwards (group A) in 104 embryo transfers and downwards (group B) in 83 transfers. No movement of embryo-associated air out of the uterine cavity, either into the cervix or the intramural portion of the fallopian tube, was observed. The clinical pregnancy rate was similar in both groups: 47.12% in group A versus 45.78% in group B. The total implantation rate/embryo transferred was 19.34% in group A compared with 20.07% in group B. The movement of the embryo transfer-associated anti-bubble is unlikely to be a factor in predicting success in donor egg IVF cycles.

For More information you can visit here: Embryo Transfers

In Vitro Fertilization/Intracytoplasmic Sperm Injection for Male Infertility.

By Goral Gandhi (Indo Nippon IVF) - Progress in the field of assisted reproduction, and particularly micromanipulation, now heralds a new era in the management of severe male factor infertility, not amenable to medical or surgical correction. By overcoming natural barriers to conception, in vitro fertilization and embryo transfer (IVF-ET), subzonal sperm insemination, partial zona dissection, and intracytoplasmatic injection of sperm (ICSI) now offer couples considered irreversibly infertile, the option of parenting a genetically related child. However, unlike IVF, which necessitates an optimal sperm number and function to successfully complete the sequence of events leading to fertilization, micromanipulation techniques, such as ICSI, involving the direct injection of a spermatozoon into the oocyte, obviate all these requirements and may be used to alleviate severe male factor infertility due to the lack of sperm in the ejaculate due to severely impaired spermatogenesis (non-obstructive azoospermia) or non-reconstructable reproductive tract obstruction (obstructive azoospermia).

ICSI may be performed with fresh or cryopreserved ejaculate sperm were available, microsurgically extracted epididymal or testicular sperm with satisfactory fertilization, clinical pregnancy, and ongoing pregnancy rates. However, despite a lack of consensus regarding the genetic implications of ICSI or the application and efficacy of preimplantation genetic diagnosis prior to assisted reproductive technology (ART), the widespread use of ICSI, increasing evidence of the involvement of genetic factors in male infertility and the potential risk of transmission of genetic disorders to the offspring, generate major concerns with regard to the safety of the technique, necessitating a thorough genetic evaluation of the couple, classification of infertility and adequate counseling of the implications and associated risks prior to embarking on the procedure. The objective of this review is to highlight the indications, advantages, limitations, outcomes, implications and safety of using IVF/ICSI for male factor infertility to enable a more judicious use of these techniques and maximize their potential benefits while minimizing foreseen complications.

For more information you can visit here: in vitro fertilization

Ant bubble Trajectory During Embryo Transfers in Donor EGG IVF does not Predict Success

By Goral Gandhi (Learn IVF Clinic) - the Transient motion of embryo transfer-associated anti bubble was observed. This prospective study was performed to determine if this anti-bubble movement can predict a successful outcome. Transabdominal ultrasound-guided embryo transfers were performed in 187 recipients receiving identical hormone replacement therapy. 

All embryo transfers were performed by the first author, using the Sureview embryo transfer catheter, in 30 ml of culture media. The observation was made of the catheter placement in relation to the endometrial surface and uterine fundus during embryo transfer. Ultrasound-guided tracking of anti-bubble within the uterine cavity was done immediately after the piston was depressed at the time of embryo deposition. 

The anti-bubble movement was upwards (group A) in 104 embryo transfers and downwards (group B) in 83 transfers. No movement of embryo-associated air out of the uterine cavity, either into the cervix or the intramural portion of the Fallopian tube, was observed. The clinical pregnancy rate was similar in both groups: 47.12% in group A versus 45.78% in group B. 

The total implantation rate/embryo transferred was 19.34% in group A compared with 20.07% in group B. The movement of the embryo transfer-associated anti-bubble is unlikely to be a factor in predicting success in donor egg IVF cycles.

 For More information, you can visit here: Embryo Transfers

Goral Gandhi, Scientific And Laboratory Director at Indo Nippon IVF in Mumbai

Goral Gandhi is a Clinical Embryologist with more than 20 years of expertise in the field of IVF and Assisted Reproductive procedures. She is in charge of the structure and foundation of many active assisted conception labs in India and one in Ghana. She is always dedicated to keeping up remarkable achievement rate at all these labs or research centers.

In her 22 year’s journey, she has taken care of thousands of IVF and ICSI cases and has helped more than 3500 couples total their families. Goral has a productive involvement in giving training in IVF and has been sorting out academic lectures and hands-on workshops on all parts of IVF including IUI, ICSI, Verification, Trouble Shooting, and Laboratory Management since the year 2000. She has trained more than 350 embryologists from 13 nations.

She has set up extremely fruitful Fertility Preservation modules at various labs and her current research projects are centered around the choice of the most reasonable and ailment free embryo along with the unique conceivable implantation potential using PGD and PGS methods.

She has also edited a reading material (textbook) on Verification. Moreover, she has co-authored more than 30 sections in different therapeutic course books and has a few publications in national and universal journals. If you want to know more about her work, visit Goral Gandhi Website: https://indonipponivf.com/mrs-goral-gandhi/

How to get better out of an Embryo transfer process in IVF ?

Embryo transfer day can come over as a crucial day for any of the persons going for an IVF treatment and this comes along with lots of stress and worries in the process for both the couples alongside. While this would be bringing a lot of hope for both the partners seeking a solution for their infertility issues, this also brings along a greater risk of making everything go in vain in a matter of few days. So when this goes along, there are certain things that both the partners must keep in mind whilst planning through for an Embryo transfer process.

1. Look out for the best doctor around

Whilst this is going to be the best and most important decisions of your life being a couple, you must go forward to look around the best doctor who can help you all the way during the process. As this would help and support your overall IVF treatment in a big manner, it would also lay down a better foundation for your dreams of attaining parenthood eventually.

2. Get along with all the diagnosis required in the process

As a person goes through an IVF treatment, there is a list of diagnostics and tests that she has to go through during the same process which might include tests like Hormone profiling, semen analysis for the male partner, Trans -vaginal scan and so on. All these tests would play a crucial role in the treatment process

3. Diet and lifestyle

If we talk about the dietary schedule to follow during the IVF treatment process, the person must intake diet rich in Folic acid as it’s been said that Folic acid reduces the chances of any sort of birth defects in the child. Moreover, the patient can also opt for Folic acid supplements in case she is not finding it feasible to go on a diet for the same. Along with Folic acid, the Multivitamins must also be considered within the same process and it’s been stated by several medical professionals that Folic acid, whilst been taken along Multivitamins, improves the chances of IVF pregnancies by a great extent.

Other than diet, the person needs to make some crucial changes to another lifestyle in order to keep the unwanted stress and anxiety at bay. This can come through implementing various relaxation techniques, medication or through yoga. Whilst has been done, this could prove as a crucial aspect of the overall embryo transfer afterward.

Embryo transfer process: How to go about it during an IVF treatment?

Embryo transfer process is a part of the IVF treatment process and it can said to be the final step in the same process as well. Being a person seeking the IVF treatment, you might have been through weeks of medications, observations along with the egg retrieval process and finally it’s the time when the Embryo is going to be transferred to the uterus of the women after getting developed in a lab for 3-5 days.

This process comes as the most anticipated moment of the whole IVF journey and after months of treatment and medications, it’s that time when you will get to know the overall result about your IVF treatment. Therefore, understanding the overall process of taking care whilst going through the same always holds the key.

The Embryo transfer process

Once the embryo is developed and cultured in a lab dish, it is then implanted in the uterus of the women who are seeking pregnancy through IVF. It is a relatively easier Embryo transfer process than the Egg retrieval process and the patient can be discharged within 2-3 hours once the process is through. Going via ultrasound, the physician will use a fine transfer catheter to place the embryos through the vagina and cervix into the uterus. Once the transfer process is through, you will then be asked to lie on your back for about 30 minutes before getting discharged.

What happens after the embryo transfer?

The embryo transfer process isn’t that tough but what happens afterward is a journey full of anxiety and stress. As there will be a gap of almost two weeks between the embryo transfer and the first pregnancy test, the period in between comes along with all the stress and impatience for the person. As a result, you will get to see some symptoms like mood swings, fatigue, slight bloating and sore breast and it would be a bit hard to guess whether these are symptoms for premenstrual or Pregnancy.

This is where the patient becomes more confused in regards to the result of the overall IVF treatment and all they can do is to wait for the first pregnancy test.

Precautions to take after the embryo transfer

Although it’s been suggested that the patient can result with her daily routines after the embryo transfer process, she is still advised of proper bed rest for some time along with the consumption of some healthy foods in the process. Moreover, the patient is strictly prohibited for the consumption of alcohol and tobacco and this must be followed religiously. Moreover, for further information on the embryo transfer process and best IVF treatment around.

Things you must not say to a person going through Infertility

Infertility always comes as a stressful phase for most of the couples and it really becomes very tough to manage all that anxiety and depression it brings along in the process. Moreover, people around the person going through this phase must also keep certain things in mind and they must follow certain Dos and Don’ts in the process of dealing with the person. Apart from all that, there are certain words and phrases that you shouldn’t utter in front of the person going through the same situation.

1. Relax and everything will be alright!

Saying someone that ‘ Relax and everything will be alright” doesn’t always work for a person going through the infertility situation as Infertility is generally caused by certain reasons like Poor sperm production, blocked Fallopian tubes or abnormal ovulation. Therefore, the person needs to see a doctor or a fertility specialist and that’s the only way his or her infertility issues would be sorted.

2. Adoption can make you conceive!

Since decades, it’s been existent like a myth in the society around that adopting a child would ultimately make you get off from your infertility issues. Whilst this would come as a good social step towards the well being of all the ‘Parentless kids” in the world around, it doesn’t hold any connection with the Infertility issues with the same person  and shouldn’t be spread further as a myth around as well.

3. Believe in God and he will make it right!

Believing in God is always a matter of faith and spirituality and one mustn’t blame God for everything. Getting the right fertility specialist for the person going through infertility is the key and thus, he or she must not be kept in the dark by using “God” as a subject of matter.

4. Blaming the person for not taking care of him or herself!

This comes as the most commonly used phrase whenever we get to deal with a person going through any type of health issue or ailment and Infertility is no exception as well. Therefore, we must not start blaming the person who is undergoing infertility issues for not taking good care of his health and daily routines as that would make the person more stressful and anxious in the process. Thus, it’s always good to motivate the person and not doing otherwise to make him feel good. Moreover, if you want to consult the best IVF specialist and center around.