Antibubble Trajectory During Embryo Transfers in Donor EGG IVF does not Predict Success

By Goral Gandhi (Learn IVF Clinic) - the Transient motion of embryo transfer-associated anti-bubble was observed. This prospective study was performed to determine if this anti-bubble movement can predict a successful outcome. Transabdominal ultrasound-guided embryo transfer was performed in 187 recipients receiving identical hormone replacement therapy.

All embryo transfers were performed by the first author, using the Sureview embryo transfer catheter, in 30 ml of culture media. The observation was made of the catheter placement in relation to the endometrial surface and uterine fundus during embryo transfer. Ultrasound-guided tracking of anti-bubble within the uterine cavity was done immediately after the piston was depressed at the time of embryo deposition. The anti-bubble movement was upwards (group A) in 104 embryo transfers and downwards (group B) in 83 transfers. No movement of embryo-associated air out of the uterine cavity, either into the cervix or the intramural portion of the fallopian tube, was observed. The clinical pregnancy rate was similar in both groups: 47.12% in group A versus 45.78% in group B. The total implantation rate/embryo transferred was 19.34% in group A compared with 20.07% in group B. The movement of the embryo transfer-associated anti-bubble is unlikely to be a factor in predicting success in donor egg IVF cycles.

For More information you can visit here: Embryo Transfers

In Vitro Fertilization/Intracytoplasmic Sperm Injection for Male Infertility.

By Goral Gandhi (Indo Nippon IVF) - Progress in the field of assisted reproduction, and particularly micromanipulation, now heralds a new era in the management of severe male factor infertility, not amenable to medical or surgical correction. By overcoming natural barriers to conception, in vitro fertilization and embryo transfer (IVF-ET), subzonal sperm insemination, partial zona dissection, and intracytoplasmatic injection of sperm (ICSI) now offer couples considered irreversibly infertile, the option of parenting a genetically related child. However, unlike IVF, which necessitates an optimal sperm number and function to successfully complete the sequence of events leading to fertilization, micromanipulation techniques, such as ICSI, involving the direct injection of a spermatozoon into the oocyte, obviate all these requirements and may be used to alleviate severe male factor infertility due to the lack of sperm in the ejaculate due to severely impaired spermatogenesis (non-obstructive azoospermia) or non-reconstructable reproductive tract obstruction (obstructive azoospermia).

ICSI may be performed with fresh or cryopreserved ejaculate sperm were available, microsurgically extracted epididymal or testicular sperm with satisfactory fertilization, clinical pregnancy, and ongoing pregnancy rates. However, despite a lack of consensus regarding the genetic implications of ICSI or the application and efficacy of preimplantation genetic diagnosis prior to assisted reproductive technology (ART), the widespread use of ICSI, increasing evidence of the involvement of genetic factors in male infertility and the potential risk of transmission of genetic disorders to the offspring, generate major concerns with regard to the safety of the technique, necessitating a thorough genetic evaluation of the couple, classification of infertility and adequate counseling of the implications and associated risks prior to embarking on the procedure. The objective of this review is to highlight the indications, advantages, limitations, outcomes, implications and safety of using IVF/ICSI for male factor infertility to enable a more judicious use of these techniques and maximize their potential benefits while minimizing foreseen complications.

For more information you can visit here: in vitro fertilization

Ant bubble Trajectory During Embryo Transfers in Donor EGG IVF does not Predict Success

By Goral Gandhi (Learn IVF Clinic) - the Transient motion of embryo transfer-associated anti bubble was observed. This prospective study was performed to determine if this anti-bubble movement can predict a successful outcome. Transabdominal ultrasound-guided embryo transfers were performed in 187 recipients receiving identical hormone replacement therapy. 

All embryo transfers were performed by the first author, using the Sureview embryo transfer catheter, in 30 ml of culture media. The observation was made of the catheter placement in relation to the endometrial surface and uterine fundus during embryo transfer. Ultrasound-guided tracking of anti-bubble within the uterine cavity was done immediately after the piston was depressed at the time of embryo deposition. 

The anti-bubble movement was upwards (group A) in 104 embryo transfers and downwards (group B) in 83 transfers. No movement of embryo-associated air out of the uterine cavity, either into the cervix or the intramural portion of the Fallopian tube, was observed. The clinical pregnancy rate was similar in both groups: 47.12% in group A versus 45.78% in group B. 

The total implantation rate/embryo transferred was 19.34% in group A compared with 20.07% in group B. The movement of the embryo transfer-associated anti-bubble is unlikely to be a factor in predicting success in donor egg IVF cycles.

 For More information, you can visit here: Embryo Transfers